New antibiotic class showing no resistance development
GmPcides are a new class of antibiotics effective against multidrug resistant gram-positive bacteria such as Staphylococcus aureus, Streptococcus pyogenes and Enterococcus ssp, including drug-resistant strains such as MRSA and VRE. GmPcides belong to a new chemical class, have new target and a new mode of action and there is no cross-resistance to other antibiotic class, i.e. they fulfil all four WHO innovativeness criteria.
QureTech Bio’s lead program is focusing on developing a new monotherapy for treatment of serious infections caused by Gram-positive bacteria. The program is supported by ENABLE-2 (financed by Vinnova) and is currently in lead optimization phase.
New class
Novel family of small molecules with excellent microbiological profile based on a robust and reliable chemical platform that allows fine tuning of properties important for drug development.
Bactericidal effect on antibiotic-resistant bacteria
GmPcides effectively kills bacteria, including MRSA in biofilm and MRSA persisters.
No pre-existing resistance
MIC90 in recent clinical isolates of S. aureus and Enterococcus ssp show a narrow distribution of MICs and there are no signs of pre-existing reduced susceptibility to GmPcides.
Key Publications
- Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics
Nye TM, Tükenmez H, Singh P, Flores-Mireles AL, Obernuefemann CLP, Pinkner JS, Sarkar S, Bonde M, Lindgren AEG, Dodson KW, Johansson J, Almqvist F, Caparon MG, Hultgren SJ. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2210912119. doi: 10.1073/pnas.2210912119.
- Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis
Flentie K, Harrison GA, Tükenmez H, Livny J, Good JAD, Sarkar S, Zhu DX, Kinsella RL, Weiss LA, Solomon SD, Schene ME, Hansen MR, Cairns AG, Kulén M, Wixe T, Lindgren AEG, Chorell E, Bengtsson C, Krishnan KS, Hultgren SJ, Larsson C, Almqvist F, Stallings CL. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10510-10517. doi: 10.1073/pnas.1818009116.
- Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors
Kulén M, Núñez-Otero C, Cairns AG, Silver J, Lindgren AEG, Wede E, Singh P, Vielfort K, Bahnan W, Good JAD, Svensson R, Bergström S, Gylfe Å, Almqvist F. Medchemcomm. 2019 Oct 17;10(11):1966-1987. doi: 10.1039/c9md00405j.